May cause stomach irritation. People with ulcers or heartburn should talk to their health care provider before using cayenne. People who are allergic to latex, bananas, kiwi, chestnuts, and avocado may also have an allergy to cayenne.
Eating cayenne as a spice is considered safe during pregnancy, but pregnant women should avoid taking cayenne as a supplement. Cayenne does pass into breast milk, so nursing mothers should avoid cayenne both as a spice and a supplement.
If you are currently being treated with any of the following medications, you should not use cayenne preparations without first talking to your health care provider.
ACE inhibitors -- Using capsaicin cream on the skin may increase the risk of cough associated with ACE inhibitors. These are medications used to regulate blood pressure, including captopril, enalapril, and lisinopril. People who take ACE inhibitors should talk to their doctor before taking cayenne.
Stomach acid reducers -- Capsaicin can cause an increase in stomach acid, lessening the effect of drugs such as cimetidine (Tagamet), famotidine (Pepcid), ranitidine (Zantac), omeprazole (Prilosec), and esomeprazole (Nexium). The same is true of over-the-counter drugs such as Maalox, Rolaids, Tums, and nonprescription versions of Tagamet, Pepcid, Zantac, and Prilosec.
Aspirin -- Capsaicin may decrease the effectiveness of aspirin to relieve pain, and may increase the risk of bleeding associated with aspirin.
Blood-thinning medications and herbs -- Capsaicin may increase the risk of bleeding associated with certain blood-thinning medications (such as warfarin and heparin) and herbs (such as ginkgo, ginger, ginseng, and garlic).
-- Regular use of cayenne may raise the absorption of theophylline to toxic levels (a medication used to treat asthma).