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  Copper Chelated
 
$3.30
Sample

10 count bottle 350 mg capsules
10 Count Bottle
350mg Capsules
$29.00
1 Month Supply

30 count bottle 350 mg capsules
90 Count Bottle
350mg Capsules
  • Overview
  • Ingredients
  • Directions
  • Side Effects

Copper is an essential trace mineral in humans. The many functions of copper include: it helps to release energy, helps in melanin production in the skin, helps in the production of blood cells and aids in the absorption and transportation of iron though the body.

Copper Chelated each capsule contains.................................1.31mg per capsule.

This product is pure nutrition; no fillers, additives or synthetic chemicals.  
The gelatin capsule complies with the requirements published in:

The United States Pharmacopoeia (USP); XXIV / National Formulary (NF) 19
The European Pharmacopoeia (EP); 3rd Edition

Kosher and Halal certified

Suggested Intake:

Dietary Supplement: 1 Capsule per day.

Theraputic Supplement: 2-3 capsules per day.

Excessive copper intake can cause nausea, vomiting, stomach pain, headache, dizziness, weakness, diarrhea, and a metallic taste in the mouth. Copper toxicity is rare but can cause heart problems, jaundice, coma, and even death. Do not use copper supplements if diarrhea is present. Water containing copper concentrations greater than 6 mg/L is associated with gastrointestinal symptoms (nausea and vomiting). If you have well water, it may be important to get the water tested for mineral content.

Copper can act as both an antioxidant and a pro-oxidant. As an antioxidant, it scavenges damaging particles in the body known as free radicals. Free radicals occur naturally in the body and can damage cell walls, interact with genetic material, and possibly contribute to the aging process as well as the development of a number of health conditions. Antioxidants can neutralize free radicals and may reduce or even help prevent some of the damage they cause.

When copper acts as a pro-oxidant at times, it promotes free radical damage and may contribute to the development of Alzheimer's disease and possibly cervical dysplasia (precancerous lesions of the cervix which forms the opening to the uterus). Maintaining the proper dietary balance of copper (along with other minerals such as zinc and manganese) is important. Your doctor or dietitian can help you do this.

Signs of possible copper deficiency include anemia, low body temperature, bone fractures and osteoporosis, low white blood cell count (the cells that help fight infection), irregular heartbeat, loss of pigment from the skin, and thyroid disorders. Infants who do not have enough of this mineral tend to have poor feeding habits and lack proper growth.

Foods that contain copper include oysters, organ meats, whole grain breads and cereals, shellfish, dark green leafy vegetables, dried legumes, nuts, and chocolate.

Anemia

Copper supplementation may be beneficial for individuals with anemia (a condition characterized by low hemoglobin levels) because this mineral works together with iron to form hemoglobin.

Arthritis

Animal studies suggest that oral copper supplements reduce the development and progression of arthritis. Many people with arthritis (both rheumatoid and osteo) apply copper solutions to their skin or wear copper bracelets in hopes of relieving pain and inflammation associated with this joint condition. Reports of success with these methods, however, are mixed, but one clinical study from the 1970s did show that the copper bracelets worked better than placebo bracelets. Sweat can interfere with how well the topical copper solutions and bracelets work.

Burns

When skin is burned, a substantial percentage of micronutrients, such as copper, selenium, and zinc may be lost. This increases the risk for infection, slows the healing process, prolongs the hospital stay, and even increases the risk of death. However, people with major burns tend to lose copper more rapidly than other mineral. Although it is unclear which micronutrients are most beneficial for people with burns, many clinical studies suggest that a multivitamin including copper and other minerals may aid in the recovery process.

Inflammatory bowel disease (IBD)

People with the inflammatory bowel diseases (IBD) ulcerative colitis and Crohn's disease cannot absorb essential vitamins and minerals, such as copper, as well as healthy individuals. When treating IBD, clinicians often recommend a multivitamin containing essential minerals.In addition, inflammatory bowel disease may be related to oxidation or damage caused by free radicals. In fact, copper levels may be low in the inflamed tissue of those with IBD, particularly Crohn's disease.

Finally, a laboratory animal study found a deficientcy of copper in rats tend to have elevated blood sugar levels over time, indicating a possible connection between low copper and diabetes. A clinical study including people with diabetes, however, found very different results. Copper levels were higher in people with diabetes compared to those without. In fact, the higher the copper level, the more likely the person was to have complications from the diabetes, including retinopathy (damage to the retina of the eye), high blood pressure, or vascular disease.

Lung Cancer

In one clinical study that followed over 1,600 patients with lung cancer found that dietary zinc and copper intakes are associated with reduced risk of lung cancer. The protective effects of dietary copper were seen in all ages, weight, and smoking.

Dietary Sources:

Among the best dietary sources of copper are:

  • Seafood (such as oysters, squid, lobster, mussels, crab, and clams)

  • Organ meats (such as beef liver, kidneys, and heart)

  • Nuts and nut butters (such as cashews, filberts, macadamia nuts, pecans, almonds, and pistachios)

  • Legumes (such as soybeans, lentils, navy beans, and peanuts)

  • Chocolate (such as unsweetened or semisweet baker's chocolate and cocoa)

  • Enriched cereals (such as bran flakes, shredded wheat, and raisin bran)

  • Fruits and vegetables (such as dried fruits, mushrooms, tomatoes, potatoes, sweet potatoes, bananas, grapes, and avocado)

  • Blackstrap molasses

  • Black pepper

Available Forms:

Multivitamins that include minerals generally provide copper. But, copper is also available as an individual oral supplement. Copper can also be found as a healing bracelet, topical gel, and in topical solutions.

How to Take It:

The best way to get enough copper is through your diet. Proper absorption and metabolism of copper requires an appropriate balance with the minerals zinc and manganese. The following lists provide the recommended daily dietary intake of copper for children and adults from the Dietary Guidelines for Americans 2005, part of the U.S. Deptartment of Health and Human Services.

Pediatric

For infants from birth to 6 months: The recommended daily intake is 200 mcg.

For infants 7 - 12 months: The recommended daily intake is 220 mcg.

For children 1 - 3 years: The recommended daily intake is 340 mcg.

For children 4 - 8 years: The recommended daily intake is 440 mcg.

For children 9 - 13 years: The recommended daily intake is 700 mcg.

For children 14 - 18 years: The recommended daily intake is 890 mcg.

Copper for children should be obtained from foods. Copper supplements should not be given to children.

Adult

For adults 19 years and older: The recommended daily intake is 900 mcg.

For pregnant females: The recommended daily intake is 1,000 mcg.

For breast-feeding females: The recommended daily intake is 1,300 mcg.

Adults taking copper supplements should also take zinc supplements (8 - 15 mg of zinc for every 1 mg of copper) as an imbalance of these two minerals can cause other health conditions.

Precautions:

Excessive copper intake can cause nausea, vomiting, stomach pain, headache, dizziness, weakness, diarrhea, and a metallic taste in the mouth. Copper toxicity is rare but can cause heart problems, jaundice, coma, and even death. Do not use copper supplements if diarrhea is present. Water containing copper concentrations greater than 6 mg/L is associated with gastrointestinal symptoms (nausea and vomiting). If you have well water, it may be important to get the water tested for mineral content.

Copper toxicity may occur from using copper cookware and from water supplied by copper pipes on a regular basis. Copper can leach out of pipes into water, especially hot water, if it sits in copper pipes for an extended period of time. It is best to always cook with cold water. Flushing the system by running cold water for 2 - 3 minutes is an effective way to reduce copper. Also, it is best to avoid unlined copper cookware since copper can leach into acidic foods, such as vinegar, tomato, or citrus. If you have blue-green stains around your faucet or sink, or if you detect a metallic taste to your water, you may want to have your water tested by a certified laboratory.

Children and individuals with Wilson's disease, a hereditary syndrome that results in an accumulation of copper in the brain, liver, kidneys, and eyes, should not take copper supplements. Because high intakes of zinc and iron can impair absorption of copper, zinc has been used to decrease copper in people suffering from of Wilson's disease.

Possible Interactions:

If you are currently being treated with any of the following medications, you should not use copper supplements without first talking to your health care provider.

Birth control medications and estrogen following menopause -- Birth control medications and estrogen replacement for post-menopausal women can increase blood levels of copper. Therefore, copper supplements are not appropriate and may be cause for concern in individuals taking either of these medications.

Nonsteroidal anti-inflammatory drugs (NSAIDs) -- Copper binds to NSAIDs (such as ibuprofen and naproxen) and appears to enhance their anti-inflammatory activity.

Penicillamine -- Penicillamine (a medication used to treat Wilson's disease and rheumatoid arthritis) reduces copper levels that may be the intended use, as in the case of Wilson's disease.

Allopurinol -- Test tube studies suggest that allopurinol (Zyloprim), a medication used to treat gout, may reduce copper levels.

Cimetidine -- Animal studies show that cimetidine (Tagamet), a medication used to treat ulcers and gastric esophageal reflux disease (when acid from the stomach enters the esophagus and causes heartburn and indigestion), may elevate copper levels in the body leading to damage of the liver and other organs.

Nifedipine -- In a human study, a lower concentration of copper was found in red blood cells after use of nifedipine (Procardia or Adalat).

Zinc -- Several laboratory and human studies have found that high levels of supplemental zinc taken over extended periods of time may result in decreased copper absorption in the intestines and copper deficiency. However, some studies in humans suggest that high dietary zinc may not interfere with the actual tissue or plasma concentrations of copper. Ask your health care provider if you need zinc and copper supplementation.

Signs of Copper Deficiency

Anemia

Faulty Nerve Development

Bone Disease

Abnormal Skin Pigmentation

Difficulty Breathing

Faulty Bone Development

Skin Eczema

Abnormal Hair Pigmentation

Red Blood Cell Rupture

Decreased Sense of Taste

Weakness

Skin Sores

Signs of Copper Toxicity

Abdominal Pain

Enlargement of Liver

Liver Cirrhosis

Enlargement of Spleen

Increased Blood Pressure

Increased Fat in Feces

Lack of Sleep

Jaundice

Emotional Agitation

Decreased Zinc to Brain

 

 

Supporting Research

Lih-Brody L, Powell SR, CAggett PJ. An overview of the metabolism of copper. Eur J Med Res. 1999;4:214-216.

Araya M, Pizarro F, Olivares M, Arredondo M, Gonzalez M, Mendez M. Understanding copper homeostasis in humans and copper effects on health. Biol Res. 2006;39(1):183-7.

Asseth J, Haugen M, et al. Rheumatoid arthritis and metal compounds -- perspectives on the role of oxygen radical detoxification. Analyst. 1998;123:3–6.

Berg G, Kohlmeier L, Brenner H. Effect of oral contraceptive progestins on serum copper concentration. Eur J Clin Nutr. 1998;52(10):711-715.

Berger MM, Spertini F, Shenkin A, et al. Trace element supplementation modulates pulmonary infection rates after major burns: a double-bline, placebo-controlled trial. Am J Clin Nutr. 1998;68(2):365-371.

Bugel, S., Harper, A., Rock, E., O'Connor, J. M., Bonham, M. P., and Strain, J. J. Effect of copper supplementation on indices of copper status and certain CVD risk markers in young healthy women. BrJ Nutr 2005;94(2):231-236.

Camara K, Danao-Camara T. Awareness of, use and perception of efficacy of alternative therapies by patients with inflammatory arthropathies. Hawaii Med J. 1999;58(12):329-332.

Christen Y. Oxidative stress and Alzheimer's disease. Am J Clin Nutr. 2000;71(2):621S-629S.

Clemente C, Russo F, Caruso MG et al. Ceruloplasmin serum level in post-menopausal women treated with oral estrogens administered at different times. Horm Metab Res. 1992;24:191.

Crews MG, Taper LJ, Ritchey SJ. Effects of oral contraceptive agents on copper and zinc balance in young women. Am J Clin Nutr. 1980;33:1940.

Cunningham JJ. Micronutrients as nutriceutical interventions in diabetes mellitus. J Am Coll Nut. 1998;17(1):7-10.

De-Souza DA, Greene LJ. Pharmacological nutrition after burn injury. J Nutr. 1998;128:797-803.

Dietary Guidelines for Americans 2005. Rockville, MD: US Dept of Health and Human Services and US Dept of Agriculture; 2005.

Dorea JG, Ferraz E, Queiroz EF. [Effects of anovulatory steroids on serum levels of zinc and copper]. Arch Latinoam Nutr. 1982;32(1):101-110.

Geerling BJ, Badart-Smook A, Stockbrügger RW, Brummer R-JM. Comprehensive nutritional status in recently diagnosed patients with inflammatory bowel disease compared with population controls. Eur J Clin Nutr. 2000;54:514-521.

Geerling BJ, Stockbrugger RW, Brummer R-JM. Nutrition and inflammatory bowel disease: an update. Scand J Gastroenterol. 1999;34(suppl 230):95-105.

Harless W, Crowell E, Abraham J. Anemia and neutropenia associated with copper deficiency of unclear etiology. Am J Hematol. 2006;81(7):546-9.

Horwitt MK, Harvey CC, Dahm CH Jr. Relationship between levels of blood lipids, vitamins C, A, and E, serum copper compounds, and urinary excretions of tryptophan metabolites in women taking oral contraceptive therapy. Am J Clin Nutr. 1975;28(4):403-412.

Institute of Medicine. Dietary Reference Intakes for Vitamin A, Vitamin K, Arsenic, Boron, Chromium, Copper, Iodine, Iron, Manganese, Molybdenum, Nickel, Silicon, Vanadium, and Zinc. Washington, DC: National Academy Press; 2004.

lein D, Lichtmannegger J, Heinzmann U, Summer KH. Dissolution of copper-rich granules in hepatic lysosomes by D-penicillamine prevents the development of fulminant hepatitis in Long-Eva

ollier KP, Reddy GM, Cerchia R, Kahn E, et al. Increased oxidative stress and decreased antioxidant defenses in mucosa of inflammatory bowel disease. Digest Dis Sci. 1996;41(10):2078-2086.

Mahabir S, Spitz MR, Barrera SL, Beaver SH, Etzel C, Forman MR. Dietary zinc, copper and selenium, and risk of lung cancer. Int J Cancer. 2007;120(5):1108-15.

Malkiel S, Har el R, Schwalb H, et al. Interaction between allopurinol and copper: possible role in myocardial protection. Free Radic Res Commun. 1993; 18(1):7-15.

Mazzetti I, Grigolo B, Borzai RM, Meliconi R, Facchini A. Serum copper/zinc superoxide dismutase levels in patients with rheumatoid arthritis. J Clin Lab Res. 1996;26(4):245–249.

Miche H, Brumas V, Berthon G. Copper(II) interactions with nonsteroidal antiinflammatory agents. II. Anthranilic acid as a potential. OH-inactivating ligand. J Inorg Biochem. 1997 Oct;68(1):27-38.

Milanino R, Marrella M, Crivellente F, Benoni G, Cuzzolin L. Nutritional supplementation with copper in the rat. Effects on adjuvant arthritis develoment and on some in vivo- and ex vivo-markers of blood neutrophils. Inflamm Res. 2000;49(5):214-223.

Nagano T, Toyoda T, Tanabe H, et al., Clinical features of hematological disorders caused by copper deficiency during long-term enteral nutrition. Intern Med. 2005;44(6):554-9.

Naveh Y, Weis P, Chung HR, et al. Effect of cimetidine on tissue distribution of some trace elements and minerals in the rat. J Nutr. 1987;117:1576-1587.

Olivares M, Uauy R. Copper as an essential nutrient. Am J Clin Nutr. 1996;63:791S–796S.

Otomo S, Sasajima M, Ohzeki M, Tanaka I. Effects of D-penicillamine on vitamin B6 and metal ions in rats [in Japanese]. Nippon Yakurigaku Zasshi. 1980;76(1):1-13.

Pennington JA, Schoen SA. Total diet study: estimated dietary intakes of nutritional elements. Int J Vitam Nutr Res. 1996;66:350–362.

Rottkamp CA, Nunomura A, Raina AK, Sayre LM, Perry G, Smith MA. Oxidative stress, antioxidants, and Alzheimer's disease. Alzheimer Disease Assoc Disorders. 2000;14(Suppl 1):S62-S66.

Southwood TR, Malleson PN, Roberts-Thomson PJ, Mahy M. Unconventional remedies used for patients with juvenile arthritis. Pediatrics. 1990;85(2):150-154.

Sturniolo GC, Mestriner C, Lecis PE, et al. Altered plasma and mucosal concentrations of trace elements and antioxidants in active ulcerative colitis. Scand J Gastroenterol. 1998;33(6):644-649.

Struthers GR, Scott DL, Scott DG. The use of 'alternative treatments' by patients with rheumatoid arthritis. Rheumatol Int. 1983;3(4):151-152.

Tamura T, Turnlund JR. Effect of long-term, high-copper intake on the concentrations of plasma homocysteine and B vitamins in young men. Nutrition. 2004;20(9):757-9.

Thomson SW, Heimburger DC, Cornwell PE, et al. Correlates of total plasma homocysteine: folic acid, copper, and cervical dysplasia. Nutrition. 2000;16(6):411-416.

Turnlund, J. R., Keyes, W. R., Kim, S. K., and Domek, J. M. Long-term high copper intake: effects on copper absorption, retention, and homeostasis in men. Am J Clin Nutr 2005;81(4):822-828.

Tyrer LB. Nutrition and the pill. J Reprod Med. 1984;29(Suppl 7):547-550.

Uauy R, Olivares M, Gonzalez M. Essentiality of copper in humans. Am J Clin Nutr. 1998;67(5 suppl):952S–959S.

Voruganti VS, Klein GL, Lu HX, et al., Impaired zinc and copper status in children with burn injuries: need to reassess nutritional requirements. Burns. 2005;31(6):711-6.

Walker WR, Beveridge SJ, Whitehouse MW. Dermal copper drugs: the copper bracelet and cu(II) salicylate complexes. Agents Actions Suppl. 1981;8:359-367.

Walker WR, Keats DM. An investigation of the therapeutic value of the 'copper bracelet'-dermal assimilation of copper in arthritic/rheumatoid conditions. Agents Actions. 1976;6(4):454-459.

Walter Rm jr, Uriu-hare JY, Olin KL, Oster MH, Anawalt BD, Critchfield JW, Keen CL. Copper, zinc, manganese, and magnesium status and complications of diabetes mellitus. Diabetes Care. 1991;14(11):1050-1056.

Wapnir RA. Copper absorption and bioavailability. Am J Clin Nutr. 1998;67(5):1054s.
 

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