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The Benefits, Science & Testimonials

Methyl sulfonylmethane MSM
10 Count Bottle
1000mg Capsules
1 Month Supply
Methyl sulfonylmethane MSM
180 Count Bottle
1000mg Capsules
  • Overview
  • Ingredients
  • Directions
  • Side Effects


MSM, Methylsulfonylmethane, is an organic sulfur compound that is contained in everyone's blood and most foods.

Biologically active sulfur has preventive and therapeutic properties.Some experts believe that, like other sulfur compounds, it's a necessary building block for proteins, especially those found in the hair, muscles, and connective tissue of the joints and skin.

The element Sulfur is also found in insulin and bile acid. MSM is an effective remedy for back pain, arthritis and a host of other disorders. MSM appears to inhibit pain impulses that travel along nerve fibers, acting as an analgesic.

MSM Methylsulfonylmethane...........................................1000mg of

MSM contains 340mg of elemental sulfur per capsule.

This product is pure nutrition; no fillers, additives or synthetic chemicals.  
The gelatin capsule complies with the requirements published in:

The United States Pharmacopoeia (USP); XXIV / National Formulary (NF) 19
The European Pharmacopoeia (EP); 3rd Edition

Kosher and Halal certified

1 capsule 2 times per day.
Best taken with a glass of water one half hour prior to taking a meal.

2 capsules 3 times per day with meal.
As it tends to stimulate one's energy level, it is generally advisable not to take it prior to retiring for the night.

Easily soluble in water product can be empted from capsule into distilled water.

It is recommended to gradually increase the dosage from two capsules twice daily, and not to increase the dose as long as detoxification symptoms persist.

Although uncommon, these symptoms may include nausea and headaches

Optimal Therapeutic Dosage

The optimal dosage depends on the nature and intensity of the complaints. In most cases, it is sufficient to take an initial dose of three 1-gram capsule twice daily.

People with serious ailments have been shown to benefit from higher dosages, up to 4 (four) 1,000mg Capsules three times daily. Such a high dosage may be advised to fight parasital infections.

30 Capsules per Day

Case studies have been reported in which patients did not show noticeable improvement until they received a daily dosage of 30 grams. Such extreme dosage is not generally recommended for most people, although no negative effects were reported.

Methylsulfonylmethane is one of the least toxic substances in biology, similar in toxicity to water.

Symptoms of detoxification may include diarrhea, skin rash, headache and fatigue.

Detoxification Symptoms

In practice, most people who use MSM notice very little at the onset, or may experience slight detoxification symptoms. These symptoms may include mild forms of diarrhea, skin rash, headache and fatigue.

After one week, these symptoms usually disappear. Fewer than 20% of users of MSM may feel moderately sick in the first few days of using MSM.

Intense or Moderate Symptoms

The more intense the symptoms, the greater detoxification is taking place, the more MSM is needed for its purification process. It may be advisable to reduce the dosage of MSM, and to gradually rebuild it once the symptoms disappear.


MSM has anti-inflammatory actions, combating the symptoms of:

  • Arthritis
  • Osteoarthritis
  • Fibromyalgia
  • Bladder Disorders
  • Carpal Tunnel Syndrome
  • Allergies
  • Hyperacidity
  • Parasites
  • Constipation
  • Musculoskeletal pain
  • Immunomodulation

MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS. Dosages, mechanisms of action, and rationales for use are discussed. The low toxicological profiles of these sulfur compounds, combined with promising therapeutic effects, warrant continued human clinical trails.

MSM can reduce muscle spasms, increase blood flow and contribute to the maintenance and repair of cartilage.

Studies show that MSM can help to delay the growth of certain types of cancerous tumors.

MSM is found in foods, including fruit, alfalfa, corn, tomatoes, tea, and coffee; in human and bovine milk; and in human urine (4-11 mg/day of MSM are normally excreted in the urine).

Sulfur research on humans has focused on the role of sulfur containing amino acids, low molecular- weight thiols, and disulfides in reduction-oxidation reaction, e.g., antioxidant reactions. Blood plasma thiols can have pro-oxidant or antioxidant actions depending on the physiological circumstances, but are generally considered antioxidants.

  • Why Sulfur
  • Osteoarthritis
  • Diabetes


Following calcium and phosphorus, sulfur is the third most abundant mineral in the body. A grown person contains approximately 140 grams of sulfur (6). Nearly half of all sulfur is contained in muscular tissue, skin and bones.

OBJECTIVE: Osteoarthritis is the most common form of arthritis and the second most common cause of long-term disability among middle-aged and older adults in the United States.

METHODS: A randomized, double-blind, placebo-controlled trial was conducted. Fifty men and women, 40-76 years of age with knee Osteoarthritis pain were enrolled in an outpatient medical center. Intervention was MSM 3g or placebo twice a day for 12 weeks (6g/day total).

RESULTS: Compared to placebo, MSM produced significant decreases in WOMAC pain and physical function impairment (P<0.05). No notable changes were found in WOMAC stiffness and aggregated total symptoms scores. MSM also produced improvement in performing activities of daily living when compared to placebo on the SF-36 evaluation (P<0.05).

CONCLUSION: MSM (3g twice a day) improved symptoms of pain and physical function during the short intervention without major adverse events. The benefits and safety of MSM in managing Osteoarthritis and long-term use cannot be confirmed from this pilot trial, but its potential clinical application is examined. Underlying mechanisms of action and need for further investigation of MSM are discussed.

Osteoarthritis Cartilage. 2006 Mar;14(3):286-94. Epub 2005 Nov 23.

Insulin is a hormone excreted by the pancreas which mainly functions to regulate the blood sugar level. Insulin therefore plays an important role in the carbohydrate metabolism. Each insulin molecule consists of two amino acid chains, connected to one another by sulfur bridges. These sulfur bridges are very important for the proper functioning of insulin. Without MSM e.g., sulfur, the hormone loses its biological activity.

Life can not exist with out enzymes; their proteins control biological function in the body. For example, they regulate all metabolic processes in our bodies. Sulfur bridges are responsible for the spatial structure of enzymes. Without sulfur bridges, enzymes would lack biological activity due to deviations in their spatial structure. Deficiency in sulfur causes reduced production of biologically active enzymes, which result in a reduction of many metabolic processes. Sulfur is important for the cellular energy production in which glucose is metabolized under the release of energy.

  • Metabolism
  • Synergetic Effect
  • Elasticity


Sulfur plays a role in the electron transport system, as part of iron/sulfur proteins in mitochondria, the energy factories of the cell. Furthermore, sulfur participates in the vitamin-B Thiamine (B1) en Biotin. These vitamins are essential for converting carbohydrates into energy, by burning glucose.

Synergetic Effect

MSM is considered a potentiator of most vitamins and other nutrients, such as vitamin C, Coenzyme Q10, all B- vitamins, vitamin A, D en E, amino acids, selenium, calcium, magnesium en many others. MSM improves the cellular uptake of these nutrients, and prolongs their lives. The body can better utilize the nutrients, and taking dietary supplements is more efficient.

Some research indicates that MSM and Vitamin C should be used at a 1:1 ratio.Because the role of elemental sulfur in human nutrition has not been studied extensively.

Cell Membrane Permeability

All cells (and all organelles within cells) are surrounded by membranes. A membrane consists of two layers of molecules situated opposite of one another and consisting of an essential fatty acid on one end, and a sulfur containing amino acid on the other end. The amino acids are interconnected in such a manner that they form a surface into which the proteins and other membrane constituents are inserted and secured. These proteins are necessary for the transport through the cell membrane of many types of nutrients and waste materials.


Sulfur bridges form flexible connections between the cells and the surrounding connective tissues. This allows the cells to retain their elasticity. When sulfur is in short supply, the cell wall hardens, and the cells lose their elasticity. The transport proteins of the membrane become locked, and the membranes become less permeable. This results in a reduced transport of oxygen and nutrients into, and excretion of waste products, from the cells. This causes a shortage of oxygen and nutrients, and an accumulation of toxic metabolic waste products inside the cells. Reduced vitality and eventually degenerative diseases are the result.

Crosslinking in Collagen

MSM slows down and restores crosslinking in collagen.  Crosslinking in collagen is a natural process in scar formation, causing hard and often painful scar tissues. Particularly in the case of burn scars, in which large surface areas may be affected, this may lead to chronic pain. MSM heals scar tissue which makes the skin more flexible.


Sulfur is the sixth most abundant macromineral in breast milk and the third most abundant mineral based on percentage of total body weight.

The sulfur-containing amino acids are:

  • methionine
  • cysteine
  • cystine
  • homocysteine
  • homocystine
  • taurine
Who could Benefit from MSM

Dietary supplementation may be indicated for vegan, athletes, children, or patients with HIV. Methylsulfonylmethane (MSM), a volatile component in the sulfur cycle, is another source of sulfur found in the human diet. Increases in serum sulfate may explain some of the therapeutic effects of MSM, DMSO, and glucosamine sulfate.

MSM, can be used to increase synthesis of S-adenosylmethionine (SAMe), glutathione (GSH), taurine, and N-acetylcysteine (NAC).

MSM may be effective for the treatment of allergy, pain syndromes, athletic injuries, and bladder disorders. Other sulfur compounds such as SAMe, dimethylsulfoxide (DMSO), taurine, glucosamine or chondroitin sulfate, and reduced glutathione may also have clinical applications in the treatment of a number of conditions such as depression, fibromyalgia, arthritis, interstitial cystitis, athletic injuries, congestive heart failure, diabetes, cancer, and AIDS. Dosages, mechanisms of action, and rationales for use are discussed.

MSM is a solvent: this solvent can extract undesirable toxins form the body acting as a chelation agent. MSM is attracted to heavy metals toxic compounds Bound to the mucosa and split into an electron deficient group, MSM reacts with toxins, affects inactivation and speeds excretion. Furthermore, MSM enhances the permeability of cell membranes, making it easier for nutrients to be taken up by the cells, and waste products to be eliminated.

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All information offered is for educational purposes. Because knowledge and understanding is never static, the information on these pages will be updated as research and studies are applied to the subject matter.

Testimonials used are unsolicited by Hopewell Technologies Limited or any other person or entity associated with aforementioned cooperation.  All statements are believed to be true and to accurately display the intent of the authors of the testimonials.  

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