What is Oxidation Mender?
Oxidation Mender was formulated to remove free radicals—also known as oxidative stress— from the body. These free radicals are formed inside the human body after cellular respiration. Free radicals have been shown to cause what we call the aging process, but more importantly, have been demonstrated as a causal-relationship for many of the most pervasive diseases plaguing mankind today.
Each ingredient in Oxidation Mender was carefully selected. Only natural ingredients with published findings of induction, anti-oxidant effects were chosen. Oxidation Mender is a complex proprietary blend of synergetic plant-based ingredients also known as active phyto-agents. These selected ingredients have been demonstrated in peer reviewed studies to reverse the DNA damaging, carcinogen chemicals produced in the human body. This complex mixture of black rice extract, glutathione reduced, Alpha Lipoic Acid Reduced, superoxide dismutase, and catalase, provides protection against oxidative damage.
This product is pure nutrition; no fillers, additives or synthetic chemicals.
The gelatin capsule complies with the requirements published in:
Depending upon the severity of the metabolic disorder your body is exhibiting.
No side effects in the majority of cases.
Occasional stomach upset, eat with food if necessary
Why Do We Need Oxidation Mender?
Our cells need oxygen in order to perform the many complex reactions needed to survive. Our cells need oxygen to perform cellular respiration. Cellular respiration is the set of metabolic reactions and processes that take place in the cells of organisms to convert biochemical energy from nutrients into adenosine triphosphate (ATP). ATP is known as metabolic energy and is critical to sustain human life. Respiration is one of the key ways a cell produces energy to fuel cellular reformations. One process of cellular respiration is the break-down of polymers into smaller, more manageable pieces. When the body works perfectly the ultimate goal of cellular respiration is to take carbohydrates, disassemble them into glucose molecules, and then use this glucose to produce energy-rich ATP molecules.
However, metabolic waste is also created (a by-product) from these important metabolic reactions. Within a split-second, the ingredients in Oxidation Mender convert the waste by-products, known as reactive oxygen species, into harmless components.
The body has the natural ability to convert potential damaging by-products of natural cell respiration into harmless compounds. In fact, these by-products are useful in a healthy human body. The biologically important free radicals are the oxygen species, superoxide O•2-, the hydroxyl radical OH•, and the reactive nitrogen species NO•; each may play a significant physiological or pathophysiological role in the body.
Reactive oxygen species form as a natural by product of the normal metabolism of oxygen and have important roles in cell signaling. Phagocytes (white blood cells) such as macrophages not only release pro-inflammatory cytokines as part of the immune response, but also release lysozymes, peroxidases, elastase, and reactive oxygen species in order to damage the invading microorganism. The production of reactive oxygen species by macrophages also activates several anti-inflammatory signaling pathways as part of the feedback mechanism to control the immune system. The reactive oxygen species and reactive nitrogen species produced by phagocyte can be useful in the short term as a defense against infection, but may harm us in the long term, and certainly harms patients with chronic inflammatory diseases.
Cause of Human Diseases
The harmful free radicals associated with cell damage are the species such as superoxide, hydrogen peroxide, hypohalous acid, and hydroxyl radicals. Cells are continually subject to attack by numerous oxidative stress-inducing factors including: heat shock, heme accumulation, hypoxia (adequate oxygen supply), UV radiation, nitric oxide, cytokines, and heavy metals. The constant assault respirated on our DNA by reactive oxygen species can lead to cancer development.
Oxidation Mender is a great formulation to convert these harmful free-radicals into useful chemicals the body can recycle or safely eliminate. Our bodies are often unable to function perfectly in this world of imperfect environment and food, and toxins. We get diseases. We need something to stop the spiral downhill to worsening heath. We need something to reverse the damage. Oxidation Mender was formulated for those very reasons.
Why Oxidation Mender Is the Key to Health
Anti-tumor Activity of Black Rice Extract
The carbohydrate characteristics of rice extracts are not fully understood. Previous studies of polysaccharides from Ganoderma lucidum (Wang et al., 1997), Grifola umbellata (Miyazaki et al., 1979) and Cordyceps Ophioglossoides (Yamada et al., 1984) have shown that b-(1,3)- and a- (1,6)-D-glucan are responsible for their immunomodulating activities. However, the 1,6-a-linked glucan, isolated from rice bran and black soybean, has also been demonstrated as a stimulant of anti-tumor immunity (Takeo et al., 1988; Takeda et al., 1994).
The type of structure, polysaccharides or others, responsible for the activity of rice extracts remains to be determined. Moreover, while taken orally,
carbohydrates and proteins may be digested rapidly through gut passage. Whether this digestion is beneficial to bind to gastrointestinal epithelial cells to trigger mucosal immunity, or to enter circulation to activate peripheral peripheral blood mononuclear
In summary, stimulation of peripheral blood mononuclear cell by extracts of black rice extract both inhibits growth and induces differentiation of human leukemic cells. We are currently conducting an in vivo study using a tumor implantation model to observe the effects of these two types of rice on tumor growth and host immune responses. Hui-Fen Liao et al 2006
The active ingredients found in black rice extract are flavonoids. Flavonids of black rice are anthocyanins. The two anthocyanins are, cyanidin 3-glycoside and peonidin 3-glycoside, have been identified as the major compounds extracted from black rice (Zhang et al., 2006).
Clinical studies have reported a positive correlation between cardiovascular health status and consumption of black rice extracts. This particular rice possesses protective effects through many mechanisms, including antioxidant, anti-inflammatory, anti-proliferation, and lipid lowering effects.
Antioxidant properties of black rice have been found to exert not only the induction of superoxide dismutase, catalase (Chiang et al., 2006) and glutathione peroxidase activities (Auger et al., 2002), but also the suppression of reactive oxygen species (reactive oxygen species) and nitric oxide radicals in clinical and biological model systems (Hu et al., 2003).
Coronary Heart Disease
Supplementation of black rice extract has been shown to result in numerous advantages including improvement of antioxidant and anti-inflammatory status in patients with coronary heart disease, reduction of oxidative stress and inflammation (Wang et al., 2007), decrease in plasma lipid levels and alleviation of atherosclerotic lesions in animal models (Ling et al., 2002).
Human Leukemic Cells
In 2006 Hui-Fen Liao et al, demonstrated that the water extracts of Black rice moderately inhibit the growth of human leukemic cells and induce their differentiation into mature monocytes/macrophages. There are two ways for a natural product to act on leukemic cells, either by direct inhibition of cell proliferation or by stimulating the secretion of differentiation-inducing factors from immunocompetent cells (Ganguly and Das, 1994). Treatment of human leukemic cells with mononuclear cell-conditioned medium prepared from rice extracts (but not rice extracts) resulted in a marked inhibition of growth and increase in mature monocytic functions. This suggests that there may be mediators produced by peripheral blood mononuclear cellcapable of triggering leukemic cells to differentiate into mature, functioning cells. Therefore, we suggest that the anti-tumor activity induced by rice is due to stimulation of an immunomodulating response rather than direct inhibition of growth of leukemic leukemic cells. The results showed that black rice extracts are safe for cultured peripheral blood mononuclear cell because there was no cytotoxicity observed even at higher concentrations up to 10 mg/mL.
However, the immunopotentiating effect of rice is moderate, and not as great as medicinal herbs (Wang et al., 1997; Fisher and Yang, 2002), thus rice may not have a major therapeutic role in leukemia treatment. This moderate immunomodulating effect against leukemic cells, without cytotoxicity to normal MNC, suggests that rice might be suitable for clinical application as an adjuvant treatment in leukemic patients. Since rice is generally accepted as a staple food, black rice extract could be both good energy sources and biological response modifiers in leukemic patients.
Black Rice extract and related derivatives have been reported as being capable of modulating immune functions. Modified arabinoxylan rice bran can augment the secretion of TNF-a and IFN-c from human peripheral blood lymphocytes (Ghoneum and Jewett, 2000) and can enhance the phagocytic activity of macrophages (Ghoneum and Matsuura, 2004).
Over-view of Glutathione
Glutathione is probably the most important antioxidant present in cells. Therefore, enzymes that help generate Glutathione are critical to the body’s ability to protect itself against oxidative stress. Alcohol has been shown to deplete GSH levels, particularly in the mitochondria, which normally are characterized by high levels of Glutathione needed to eliminate the reactive oxygen species (reactive oxygen species ) generated during activity of the respiratory chain. Mitochondria cannot synthesize Glutathione but import it from the cytosol using a carrier protein embedded in the membrane surrounding the mitochondria. Alcohol appears to interfere with the function of this carrier protein, thereby leading to the depletion of mitochondrial Glutathione (Fernandez–Checa et al. 1997).
Oral Glutathione Increase Tissue Glutathion Levels
Tak Yee Aw et al. in 1991 demonstrated that oral glutathione increases tissue glutathione in animal.
Lung Disease Cause
Many lung diseases are associated with low glutathione levels, including cystic fibrosis, chronic obstructive pulmonary disease and acute respiratory distress syndrome. This study confirms that an oral dose of glutathione can increase blood, tissue and extracellular glutathione levels and that the absorption of glutathione was dependent on the cystic fibrosis transmembrane conductance regulator. It is also known that the levels of glutathione in the epithelial lining fluid are diminished in a number of lung disorders and environmental exposures including ARDS,9 idiopathic lung fibrosis, lung transplantation, HIV infection, alcohol abuse, asbestos, and cystic fibrosis. Studies in cystic fibrosis have partially illuminated mechanisms the lung uses to place glutathione into the epithelial lining fluid.
150mg/per lb is need
The pharmacokinetic profile of an oral bolus dose of Glutathione (300 mg/kg) was determined in mice. Plasma, ELF, bronchoalveolar lavage (BAL) cells and lung tissue were analyzed for Glutathione content. There was a rapid elevation in the Glutathione levels that peaked at 30 minutes in the plasma and 60 minutes in the lung, ELF and BAL cells after oral Glutathione dosing. Oral Glutathione treatment produced a selective increase in the reduced and active form of GSH in all lung compartments examined. Oral Glutathione treatment (300mg/kg) resulted in a smaller increase of Glutathione levels. To evaluate the role of CFTR in this process, Cftr KO mice and gut corrected Cftr KO-Tg mice were given an oral bolus dose of GSH (300 mg/kg) and compared to wild type mice for changes in GSH levels in plasma, lung, ELF and BAL cells. There was a 2-fold increase in plasma, a 2-fold increase in lung, a 5-fold increase in ELF, and a 3-fold increase in BAL cell GSH levels at 60 minutes in wild type mice, however Glutathione levels only increased by 40% in the plasma, 60% in the lung, 50% in the ELF*, and 2-fold in the bronchoalveolar lavage cells within the gut corrected Cftr KO-Tg mice.
* ELF gen, a new isoform of beta-G-spectrin in the developing brain cells. Based on its expression pattern, ELF may have a role in neural stem cell development and is a marker of axonal sprouting in mid stages of embryonic development. Oncogene (2002) 21, 5255 ± 5267. doi:10.1038/sj.onc. 1205548, ELF gene expression
Liver in Detoxification
Glutathione is a vital substance in detoxification and cell. Glutathione plays a key role in the liver in detoxification reactions and in regulating the sulphur compound compounds (thiol-disulfide status) of the cell. Under conditions of oxidative stress, the liver exports oxidized glutathione into bile in a concentrative fashion, whereas under basal conditions, mainly reduced glutathione is exported into bile and blood.
Glutathione regulation in liver is based on a homeostatic feedback inhibition mechanism. The availability of cysteine is a critical factor in the regulation of synthesis. Turnover in liver is determined mainly by the efflux of glutathione into both sinusoidal blood and bile and its subsequent degradation. The constituents of exported glutathione are conserved by hydrolysis and cellular uptake mainly in the kidney and intestine as governed by brush-border -y-glutamyltranspeptidase. Thus, one can view the liver as a glutathione-generating factor which supplies the kidney and intestines with the constituents for glutathione resynthesis.
Glutathione Levels Linked to Cell Survival
Ability of oral Glutathione to serve as a precursor for hepatic GSH. Comparison with other precursors
Excessive L-cysteine Gives Rrise to Free Radicals Damage
In liver, L-cysteine availability is the limiting factor for Glutathione synthesis (Tateishi et al. 1974); therefore, the supply of this amino acid is essential to restore the physiological levels of Glutathione. However, administration of free L-cysteine is dangerous because of its toxicity. The toxicity of this amino acid has been demonstrated in several types of cells and organs such as brain (Olney et al. 1972; Viiia et al. 1983a) and liver (Viiia et ul. 1980). In isolated hepatocytes, we observed that incubation with L-cysteine promotes a decrease in Glutathione levels (Viiia et ul. 1978) and several other signs of cytotoxicity. These side effects are due to very rapid auto-oxidation (Viiia et al. 1983b) which gives rise to free radicals (Saez et al. 1982). The toxic effects of L-cysteine do not occur when the oxidation rate of the amino acid is maintained very low (Beatty & Reed, 1980); therefore, it is important that L-cysteine reaches the liver slowly as is the case after the administration of oral Glutathione. All these factors explain why the cell accumulates free thiols as Glutathione, which acts as a reservoir of L-cysteine (Tateishi et al. 1977).
Glutathione is not an essential nutrient (meaning it does not have to be obtained via food), since it can be synthesized in the body from the amino acids L-cysteine, L-glutamic acid, and glycine.
What is R-Alpha Lipoic Acid
According to the American Cancer Society in 1937 researchers first identified R alpha lipoic acid (know here after as lipoic acid) isolated from bacteria, this compound that was investigated then, in 1939 other research demonstrated the antioxidant activity of lipoic acid.
Dr. Bilska et al. 2005, stated that naturally occurring alpha lipoic acid was isolated from bovine liver in 1950. When one is looking of natural Lipoic acid one needs to keep in mind that only the R- isomer is naturally synthesized by animals or plants organisiums and is easily bound to protein. R alpha lipoic acid was first believed to be part of vitamin B complex. Present the majority of research demonstrates that lipoic acid is not a vitamin. It is synthesized in human and animal body in mitochondria (The engine of the cells.), where, similarly as in bacterial and plant cells, octanoic acid and cysteine, which is the source of sulfur, are direct precursors of lipoic acid.
Alpha Lipoic Acid improves Liver Function
Alpha lipoic acid was shown to be hepatoprotective to improve liver circulation, and treat chronic liver
Diabeties and Alpha Lipoic Acid
One of the most studied clinical uses of alpha lipoic acid is the treatment of diabetes and diabetic neuropathy alpha lipoic acid has also been used experimentally and/or clinically to prevent organ dysfunction, reduce endothelial dysfunction and improve albuminuria, treat or prevent cardiovascular disease, accelerate chronic wound healing, reduce levels of ADMA in diabetic end-stage renal disease patients on hemodialysis, burning mouth syndrome, reduce iron overload, treat metabolic syndrome, improve or prevent age-related cognitive dysfunction, prevent or slow the progression of Alzheimer’s Disease, prevent erectile dysfunction (animal models but anecdotally applies to humans as well), prevent migraines, treat multiple sclerosis treat chronic diseases associated with oxidative stress reduce inflammation, inhibit advanced glycation end products (AGE), treat peripheral artery disease.
Free Radicals Linked to Heart Disease
One of the causes of heart disease is free radical damage this process has been implicated as a factor in the aging process of the heart and other organs inducing diseases.
According to the Center for Disease Control and Prevention CDC Heart disease has been the leading cause of death in the United States for the past 80 years and is a major cause of disability. A new approach to treating heart disease is needed, unless we change directions this statistic will not change. Heart aging is accompanied by changes that are progressive, pervasive, injurious to one’s health, and, as far as allopathic medicine is concerned is, irreversible.
Cardiovascular diseases such as hypertension, atherosclerosis, and congestive heart failure are at epidemic proportions in the elderly population, and are the leading cause of morbidity and mortality among this group.
Cardiovascular autonomic neuropathy is characterized by reduced heart rate variability, and is associated with increased risk of mortality in diabetic patients. In a randomized controlled trial of 72 patients with type 2 diabetes mellitus and reduced heart rate variability, oral supplementation with 800 mg/day of lipoic acid for 4 months resulted in significant improvement in 2 out of 4 measures of heart rate variability compared to placebo, Dr. Ziegler D et al. 1997.
Lipoic Acid Restored Myocardial Vitamin C Levels and
Inflammation, such as the destruction of joints, the synovial fluid that lubricates joints and one of its components (i.e., hyaluronic acid), as well as activation of inflammation–promoting signaling molecules called cytokines
Increasing evidence suggests that aging may be a consequence of the normal, long–term exposure to reactive oxygen species and the accumulation of oxidized, damaged molecules within the cell—a process that could be likened to a lifetime of “rusting away.”
Accordingly, the health benefits of administering antioxidants such as vitamins E and C or other compounds are the subject of much current research, and clinical trials employing antioxidants in the treatment of various conditions are under way. For example, some therapeutic interventions with antioxidants have shown success or promise in the treatment of Parkinson’s disease and in reducing the toxicity of the cancer medication adriamycin. Not all instances of reactive oxygen species production are detrimental to the organism, however. One beneficial effect is the production of reactive oxygen species by certain immune cells in order to destroy invading foreign organisms (Rosen et al. 1995). Furthermore, recent evidence suggests that reactive oxygen species, especially hydrogen peroxide, may be important in signal transduction mechanisms in cells and thus may be an integral component of cellular physiology and metabolism (Lander 1997). Defeng Wu et al.
Fortunately, our bodies have a good defense system to deal with free radicals. In forms of enzymes designed to change the free radical into a non-toxic substance. Choosing fruits and vegetables that are “dark and tart” really is good to maintain good health. We should strive to reach our nutritional goals with the daily foods we consume, although that is not always possible when one already has one of the aforementioned diseases.
Chemicals in food, called antioxidants such as Anthocyanins are some of the most powerful flavonoids. Anthocyanins are able to disarm free radicals by stopping the damage they produce. In fact Pei-Ni Chen, in 2005 studied the anticancer effects of Anthocyanins. From these results, we believe that cyanidin 3-glucoside and peonidin 3-glucoside inhibit tumor cell growth and cell proliferation and also induce apoptosis in tumor cells.
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